AURA Biomedical

AURA Biomedical Engine is an AI-powered biomedical research and
drug discovery platform for scientists, researchers, students,
and biotechnology professionals. AURA synthesizes data across 8+
global biomedical databases to deliver target intelligence, 3D
structural visualization, clinical safety analytics, and
pharmacological profiling.

KEY FEATURES & CAPABILITIES
• Target Score & Intelligence Brief: Evaluates target
feasibility with an automated 0–100 score synthesizing
bioactivity, GTEx tissue expression specificity, FDA safety logs,
and clinical trial progression likelihood.
• ADMET & Lipinski Drug-Likeness Spider Chart: Analyzes
absorption, distribution, metabolism, excretion, and toxicity
profiles. Compares molecular weight, LogP lipophilicity, H-bond
donors/acceptors, and polar surface area against Lipinski
boundaries.
• 3D Protein Conformer Visualizer & Dual Overlay: Renders
interactive 3D cartoon representations powered by 3Dmol.js.
Overlays predicted AlphaFold structures against RCSB PDB crystal
conformers to analyze structural alignment.
• FDA Safety & Adverse Event Analytics: Accesses OpenFDA safety
logs, patient reaction statistics, hospitalization ratios, fatal
outcome frequencies, and demographic gender breakdowns. Exports
reaction data to CSV.
• Clinical Trials Intelligence & Outcome Tracking: Tracks study
progress, phase II/III distributions, sponsor portfolios, and
historical success rates via the ClinicalTrials.gov API.
• Sequence Homology & BLAST Explorer: Searches amino acid
sequences or UniProt accession IDs to scan sequence alignment
identity and identify homologous protein targets.
• Genomics & Tissue Expression Profiling: Displays Ensembl
genomic loci, splice transcript isoforms, gnomAD constraint
scores (pLI / LOEUF), and GTEx median tissue expression levels
across human tissues.
• Comparative Matrix & Heatmap Drawer: Compares multiple target
leads side-by-side in a color-coded metric heatmap.

LIVE DATABASE INTEGRATIONS
• UniProtKB & RCSB PDB (Protein Sequences & 3D Structures)
• AlphaFold EBI Database (3D Structure Predictions)
• OpenFDA (Drug Safety & Adverse Event Reports)
• ClinicalTrials.gov (Global Clinical Trial Registries)
• ChEMBL & PubChem (Bioactivity & Chemical Descriptors)
• GTEx Portal & Ensembl (Expression & Genomic Structures)
• Europe PMC (Scientific Literature & Publications)

PRIVACY & COMPLIANCE
AURA does not track users or contain advertising networks.
Searches and screening library items can be stored with cloud
persistence.

Disclaimer: AURA Biomedical Engine is designed exclusively for
scientific research, educational, and reference purposes. It is
not intended for medical diagnosis, clinical decision-making, or
direct patient care.

Recent changes:
Initial release of AURA Biomedical Engine:
• AI Target Feasibility Score & Executive Intelligence Briefing
• 3D Protein Conformer Superposition & AlphaFold/PDB Viewer
• ADMET & Lipinski Rule Drug-Likeness Spider Chart
• OpenFDA Adverse Event Safety Analytics & Reaction Logs
• ClinicalTrials.gov Intelligence & Outcome Tracking
• Sequence Homology & BLAST Explorer Tool