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iTIVA is a pharmacokinetic/pharmacodynamic simulation program that provides information about the distribution of drugs based on mathematical models and calculates a dose required to achieve the desired target, plasma, or effect-site concentration, like a TCI pump (target controlled infusion), calculating schemes that can be implemented in volumetric infusion pumps based on pharmacokinetic principles to guide your TIVA or balanced Anesthesia. So you can now easily do manual TCI

Pharmacokinetic models

iTIVA has 25 drugs and more than 55 pharmacokinetic models, that are updated continuously:

-Remifentanil - ULTIVA
-Fentanyl

-Hydromorphone
-Morphine
-Sufentanil

-Alfentanil

-Ketamine
-Procaine
-Lidocaine

-Propofol
 - DIPRIVAN
-Dexmedetomidine - PRECEDEX
-Midazolam

-Penthotal
-Atracurium
-Cisatracurium
-Vecuronium
-Rocuronium
-Tranexamic
-Magnesium Sulfate
-Diazepam
-Heparin - ACT estimation
-Protamine

It also calculates the end-tidal (Et) for Isoflurane, Sevoflurane, Desflurane to get the MAC age based on the Mapleson formula or Lerou nomogram.

- Record intra-operative milestones (like unconsciousness, BIS value, etc..)
- Share your case with other colleagues using QR codes
- Export all recorded information as an excel file

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WARNING:
iTIVA is not designed to handle intravenous drugs for individual patients. Its use is limited to educational purposes to demonstrate pharmacokinetic principles when performing intravenous anesthesia. Therefore the user assumes all risks from the use of this application for clinical purposes.
Infusion schemes are obtained from concentrations based on models published in the medical literature; therefore concentrations achieved from these schemes can vary widely, in the same manner for clinical effects.
This application should only be used by people with extensive knowledge in Anesthesiology.

Recent changes:
- New mode to enter concentrations "Target"
-Added pre-alert sounds notifications 5 or 10 secs before real-time. Go to settings
- File manager system, now cases can be saved in files, to review them later o share with colleagues
- Select custom alert tones for iTIVA notifications: You can pick over 40 different tones. (Go to Setting-> Tones)
- Added a new ketamine model: Klamp
- Eleveld-h model renamed to Eleveld 1.0