GeneRx

GeneRX is an educational iOS application designed to demonstrate pharmacogenetic principles and help users understand how genetic variations can
influence medication response. The app provides insights about gene-drug interactions in an accessible, user-friendly format, powered by data and
guidelines from the Clinical Pharmacogenetics Implementation Consortium (CPIC).

IMPORTANT DISCLAIMER

This application is for EDUCATIONAL PURPOSES ONLY. Users should NOT use this app to make medical decisions. All medication and dosing decisions must
be made in consultation with qualified healthcare providers.

Data Attribution

This app is powered by:
- CPIC (Clinical Pharmacogenetics Implementation Consortium) - cpicpgx.org
- Comprehensive pharmacogenetic guidelines and recommendations
- Real-time API for current clinical recommendations
- Evidence-based gene-drug interaction data
- Peer-reviewed dosing guidelines

We gratefully acknowledge CPIC for making their pharmacogenetic data freely available for educational and research purposes. CPIC is a shared
project between PharmGKB and the Pharmacogenomics Research Network.

Key Features

Manual Genetic Variant Input
- Select from 33+ CPIC-annotated pharmacogenetic genes
- Choose specific diplotype variants based on CPIC data
- Build a personal variant profile for educational exploration

Comprehensive Drug Database
- Access to 3,803+ medications from CPIC/PharmGKB database
- 87 drugs with specific CPIC dosing guidelines
- Search functionality for finding specific medications
- Clear indicators for drugs with CPIC guidelines

Risk Level Visualization
- Color-coded recommendations based on CPIC guidelines:
- Green: Standard dosing appropriate
- Orange: Dose adjustment may be needed
- Red: Consider alternative medication
- Visual learning about CPIC medication safety classifications

Real-Time CPIC API Integration
- Fetches current recommendations directly from CPIC API
- Displays CPIC evidence levels (Strong, Moderate, Optional)
- Direct links to official CPIC guidelines
- Most up-to-date CPIC recommendations

Educational Use Cases

- Students: Learn pharmacogenetic concepts using real CPIC data
- Healthcare Trainees: Understand CPIC guidelines and clinical implementation
- Patients: Educational preparation for pharmacogenetic testing discussions
- Educators: Demonstrate CPIC guidelines in classroom settings
- General Public: Increase awareness of precision medicine

Privacy and Safety

- No data persistence between sessions
- No user accounts or registration required
- Anonymous usage only
- No tracking or analytics
- Session-only storage
- Educational focus - not for clinical use

Sample Gene-Drug Interactions

All interactions based on official CPIC guidelines:
- TPMT + Thiopurines (azathioprine, mercaptopurine)
- CYP2C19 + Clopidogrel, SSRIs, PPIs
- CYP2D6 + Codeine, Tramadol, Antidepressants
- SLCO1B1 + Statins (simvastatin, atorvastatin)
- CYP2C9/VKORC1 + Warfarin
- DPYD + Fluoropyrimidines (5-FU, capecitabine)
- HLA-B + Carbamazepine, Abacavir
- And all other published CPIC gene-drug pairs

CPIC Resources:
- Official Website: cpicpgx.org
- Guidelines: cpicpgx.org/guidelines
- API Documentation: api.cpicpgx.org

Important Notes

- Educational tool demonstrating CPIC pharmacogenetic guidelines
- Not a substitute for professional medical advice
- Interpretation of CPIC guidelines requires qualified healthcare providers
- Always consult medical professionals for medication decisions
- For educational and informational purposes only